Seminar Series Spring 2018
Tokyo Medical and Dental University
Associate Professor with the Institute of Biomaterials and Bioengineering
will be presenting
“A new concept for hydroxyapatite in bone remodeling -the nano structure and response to mechanical strain”
Because of their excellent biocompatibility and osteoconductivity, ceramic biomaterials are clinically utilised as bone grafts for the reconstruction of injured bone tissues. Modification of the ceramic surface, leading to enhanced interaction with osteogenic cells in bone tissues, can improve the osteoconductive properties of bone grafts. The fundamental concept for bone tissue engineering is to use the natural biological responses in the host body. Here, we explored the biophysical properties of bone tissue in order to develop a rationale for improved ceramic bone grafts. Mechanical loading in bone tissue induces an electrical potential generated by piezoelectricity arising from displacement of collagen fibrils. The electrical potential is stored in collagen fibrils as well as apatite minerals. The stable electrical potentials stored in apatite minerals are enough to stimulate the osteogenic cells during bone remodeling. Furthermore, we observed that bone, when polarized electrically by external voltage, depolarized by two mechanisms. Specifically, carbonate incorporation and electrical charges in bone minerals are important factors in bone piezoelectricity. These factors modulated osteogenic cell behaviours such as the osteoclastogenesis of peripheral mononuclear blood cells and the differentiation of mesenchymal stem cells into osteoblasts. Understanding the osteoconduction mechanism may allow us to design new biomaterials and select biomaterials for implantation that will last the lifetime of the recipient.
Miho Nakamura earned a Ph.D. in Biomaterials in 2007 and a Master’s Degree in Medical Science in 2003 from Tokyo Medical and Dental University. Dr. Nakamura has received several awards, such as: The International Society for Ceramics in Medicine Excellence Award in 2016, Award for Young Researcher in The Ceramic Society of Japan in 2014, Award for Young Researcher in Japanese Society for Biomaterials in 2013, Award for Encouragement of International Exchange in Japanese Society for Biomaterials in 2012, Award for Young Researcher in Japanese Association of Inorganic Phosphorus Chemistry in 2010, and Award for Encouragement of Research in Materials Science in 2008. Dr. Nakamura is presently the Associate Professor with the Institute of Biomaterials and Bioengineering at Tokyo Medical and Dental University in Tokyo, Japan. She is also a Visiting Professor with the Department of Anatomy and Cell Biology at the University of Oulu in Oulu, Finland.
Thursday, January 18, 2018 @ 3:30 PM in Burson 115 Refreshments served at 3:15 PM