Dr. Brian Kuhlman
Department of Biochemistry & Biophysics, UNC Chapel Hill
will be presenting
“COMPUTATIONAL DESIGN OF PROTEIN INTERACTIONS AND SWITCHES”
The molecular modeling program Rosetta has been used to design novel protein-protein interactions and protein switches that respond to light. The designed interactions make use of stabilizing anchor points such as metal binding and beta-strand interactions. The designed photoactivable proteins incorporate the naturally occurring LOV domain from plants, and show increased binding affinity for specified binding partners in the light. These binding events have been used to control gene transcription and protein localization with blue light.
Friday, April26, 2013 @ 1:30 PM in Bioinformatics 105