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ACS video contest: How will nano change the world?
NANOVEHICLES FOR INTRACELLULAR PROTEIN DELIVERY
Juan L Vivero-Escoto
Department of Chemistry, University of North Carolina at Charlotte
The Center for Biomedical Engineering and Science, University of North Carolina at Charlotte
Protein therapeutics holds significant promise for improving human health [1,2]. Our organism contains thousands of proteins, which perform essential functions in growth, development and metabolism regulation. Many diseases arise from the alterations in the functions of intracellular proteins . Therefore, the administration of therapeutic proteins has shown great potential in the treatment of many diseases, including cancer and diabetes. Protein therapeutics has emerged since the 1980s and represents currently a significant part of biopharmaceuticals . For example, Lantus®, an engineered protein (insulin) was one of the top ten selling biopharmaceuticals in 2009 . Moreover, protein drugs with much better therapeutic performance are developed every year. The pharmaceutical research and manufacturers of...Read More