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University of South Carolina, Department of Chemistry and Biochemistry

“INTERFACIAL CHEMISTRY OF SEMICONDUCTOR NANOCRYSTALS”

Andrew Greytak​Colloidal semiconductor nanocrystals – a type of quantum dot (QD) – are well-known as bright, highly photostable inorganic fluorophores that can be well-suited to imaging applications in biology. Additionally, the delocalized electronic states present in nanoscale semiconductors should offer distinctive ways to interact with and report on the biological environment. Such applications require good control of the interfacial chemistry of inorganic nanoparticles: in particular, to guide the formation of core/shell heterostructures to optimize brightness, and to introduce a surface coating that can enable the particles to function properly in the biological environment while limiting hydrodynamic size and avoiding quenching of the QD excited state. Significant progress has been made in identifying specific examples that comprise these features, especially for the case of metal chalcogenide semiconductors, but there remains only a limited understanding of the reaction mechanisms and thermodynamics associated with the elaboration of the surfaces of such particles with inorganic and organic layers. I will describe...

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East Carolina University, Department of Pharmacology & Toxicology, Brody School of Medicine

“UNDERSTANDING MAST CELL ACTIVATION IN THE DEVELOPMENT OF SAFE NANOTECHNOLOGIES”

Jared M. Brown​Concern about the use of engineered nanomaterials (ENMs) has increased significantly in recent years due to potentially hazardous impacts on human health. Mast cells are critical for innate and adaptive immune responses, often modulating allergic and pathogenic conditions. Mast cells act in response to environmental danger signals such as IL-33 and the IL-1 like receptor ST2. We have examined the involvement of mast cells and the IL-33/ST2 axis in adverse responses to ENMs. Mice with normal mast cell populations exhibit significant ENM directed systemic and pulmonary inflammation, fibrosis, altered lung function and exacerbated cardiac IR injury. In contrast, these toxicological effects of ENMs were not observed in mice deficient in mast cells or mice with mast cells unable to respond to IL-33. Lastly, we have established that certain ENMs are capable of inducing mast cell activation in vitro. Our findings establish for the first time that mast cells orchestrate adverse immune effects to ENMs giving insight into a previously unknown mechanism of toxicity...

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ANALYTICAL CHEMIST

ASSISTANT PROFESSOR POSITION

The University of North Carolina at Charlotte seeks applications and nominations for a tenure-track position in ANALYTICAL CHEMISTRY at the ASSISTANT PROFESSOR level. The successful candidate will support the mission of the Department of Chemistry, especially initiatives in nanoscale science or biochemistry, and will have a strong commitment to working with faculty, staff, and students from diverse backgrounds. Appointment to the position will be effective August 15, 2013. Required qualifications: a Ph.D. in chemistry or related area; relevant postdoctoral, academic or industrial experience; a commitment to establishing a productive, externally funded research program; and a commitment to excellence in teaching at the undergraduate and graduate levels.

We especially welcome applications from chemists interested in developing collaborations through participation in any of several interdisciplinary initiatives on campus, including the interdisciplinary Ph.D. Program in Nanoscale Science, the Bioinformatics Research Center, the Center for Biomedical Engineering and Science (CBES), the Ph.D...

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